"We provide support to clinical research teams in making key decisions when using patient reported outcome measures"
Patient Reported Outcome Measures (PROs)
At DHP Research we provide a range of services and support including:
- Development of patient reported outcomes (PRO)measures
- Development of PRO strategy
- Development of PRO Conceptual framework and Endpoint models
- Review and Update of Instructions on PRO Questionnaire
- PRO Translations: Survey or Instrument Translations with Cognitive debriefing
- PRO Psychometric Assessment Studies
- PRO Linguistic Validation Studies
- Cognitive Interviews
- PRO Validation Studies (Paper Vs. Electronic)
- Literature reviews
- Write academic scripts
- Training in PROs and research methodologies
With more than 20 years experience in the measurement of patient reported outcomes, DHP Research applies a highly rigorous process in the development of a new PRO measures across a range of conditions and diseases. This ensures that our measures meet the highest regulatory requirements in terms of reliability and validity.
The development of all our PRO measures is based on establishing a clearly defined conceptual model and framework and involves four key stages:
1. Qualitative Interviews
Ensuring the PRO measure has demonstrable content validity is essential when developing a new PRO measure. This is achieved through literature reviews in-depth qualitative interviews, focus group and other innovative methodologies such as carousel groups which are conducted with relevant patients and health care professionals. From these interviews statements are identified relating to the experiences and impact of the illness on the lives of the patients. These statements are used to develop draft versions of the measure.
2. Cognitive debriefing
The draft PRO measure is the tested in the field with a different sample of up to 12 patients to assess its face and content validity, comprehensiveness and relevance.
3. Validation survey
The PRO measure is then tested via a full validation survey with patients at points two weeks apart. The results are used to create the final version of the measure. This stage provides information to enable examination of the psychometric properties of the measure as well as evaluate administrative and respondent burden.
4. Assessment of the PRO measurement properties
The psychometric properties of the PRO measure are carefully assessed including test-retest reliability, internal consistency and construct validity, identify meaningful score differences.
5. Development of patient reported outcomes (PRO)measures
With more than 20 years experience in the measurement of patient reported outcomes, DHP Research applies a highly rigorous process in the development of a new PRO measures across a range of conditions and diseases. This ensures that our measures meet the highest regulatory requirements in terms of reliability and validity.
All the PRO measures developed by DHP Research reflect the views of and the language used by patients and are easy to administer, complete and score.
How to select an appropriate PRO measure for your clinical study - click here to download
"Using DHP Research & Consultancy to identify in-patient views and opinions on relevant patient reported outcomes was really valuable for us; it enabled us to undertake important evaluations of service, learn lessons and re map future service provision in a timely way whilst maintaining clinical focus. A very real cost efficiency."